Perhaps the most striking feature of neuronal circuits is their heterogeneity in cellular composition, and intrinsic biophysical and evoked response properties. Our lab is focused on studying this diversity within and across different neuronal classes and networks, in the context of local and long-range connectivity and the attentional state of the brain. It is our view that only a detailed quantitative understanding of the heterogeneity in connectivity and physiology of individual elements of the network can elucidate key principles underlying the design and operation of neuronal circuits in the normal and diseased brain.

Circuits and maps (clockwise from top left) Anatomical drawings of the neuronal pathways of the early olfactory and visual systems (Cajal, 1936); neuronal diversity in circuits of the retina (Jeremy Kay, Duke University); first maps indicating the organisation of the somatosensory cortex in primates (Penfield and Boldrey, 1937); the first integrative circuit (designed by Nobel Laureate Jack Kilby in 1958); the neuron equivalent circuit (Hodgkin and Huxley, 1952); the first snapshot of brain-wide connectivity onto a functionally characterised cortical neuron (Rancz et al., 2011).